diff --git a/.github/ci-nightly-test.sh b/.github/ci-nightly-test.sh
new file mode 100644
index 000000000..3ee9b739f
--- /dev/null
+++ b/.github/ci-nightly-test.sh
@@ -0,0 +1,19 @@
+#!/bin/bash
+
+set -e
+
+# We do not want to come across the ecCodes tools in the toolbox
+module unload ecmwf-toolbox
+
+module load cdo/new
+module load numdiff
+module load nccmp
+module load netcdf4/new
+module load gnuparallel/new
+module load python3
+
+cd ~masn/REGRESSION_TESTING/ecCodes
+./par-suite.sh -w $TMPDIR/install/eccodes
+
+# For debugging specific test(s)
+# ./seq-suite.sh -w $TMPDIR/install/eccodes -d -t py_
diff --git a/.github/workflows/nightly.yml b/.github/workflows/nightly.yml
new file mode 100644
index 000000000..a40ef52ee
--- /dev/null
+++ b/.github/workflows/nightly.yml
@@ -0,0 +1,16 @@
+name: nightly
+
+on:
+  workflow_dispatch: ~
+
+  # Run at 20:00 UTC every day (on default branch)
+  schedule:
+    - cron: '0 20 * * *'
+
+jobs:
+  test:
+    uses: ./.github/workflows/reusable-ci-hpc.yml
+    with:
+      eccodes: ecmwf/eccodes@${{ github.event.pull_request.head.sha || github.sha }}
+      nightly_test: true
+    secrets: inherit
diff --git a/.github/workflows/reusable-ci-hpc.yml b/.github/workflows/reusable-ci-hpc.yml
index 3db33f2d2..6ae5701a8 100644
--- a/.github/workflows/reusable-ci-hpc.yml
+++ b/.github/workflows/reusable-ci-hpc.yml
@@ -6,6 +6,10 @@ on:
       eccodes:
         required: false
         type: string
+      nightly_test:
+        required: false
+        type: boolean
+        default: false
 
 jobs:
   ci-hpc:
@@ -19,5 +23,9 @@ jobs:
           ecbuild
           ninja
           aec
+          netcdf4/new
         --parallel: 64
+        ${{ inputs.nightly_test && '--post-script: .github/ci-nightly-test.sh' }}
+        ${{ inputs.nightly_test && '--force-build: true' }}
+        ${{ inputs.nightly_test && '--cmake-options: -DENABLE_PNG=1,-DENABLE_NETCDF=1' }}
     secrets: inherit